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KMID : 0613820210310090849
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Journal of Life Science
2021 Volume.31 No. 9 p.849 ~ p.855
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Development of PLGA Nanoparticles for Astrocyte-specific Delivery of Gene Therapy: A Review
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Shin Hyo-Jung
Lee Ka-Young
Kwon Ki-Sang
Kwon O-Yu
Kim Dong-Woon
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Abstract
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Recently, as nanotechnology has been introduced and used in various fields, the development of new drugs has been accelerating. Nanoparticles have maintained blood drug concentration for extended periods of time with a single administration of the drug. The drug can then be selectively released only at the pathological site, thereby reducing side effects to other non-pathological sites. In addition, nanoparticles can be modified for selective target sites delivery for other specific diseases, with polymers being widely used in the manufacture of these nanoparticles. Poly (D,L-lactic-co-glycolic acid ) (PLGA) is one of the most extensively developed biodegradable polymers. PLGA is widely used in drug delivery for a variety of applications. It has also been approved by the FDA as a drug delivery system and is widely applied in controlled release formulations, such as in gene therapy treatments. PLGA nanoparticles have been developed as delivery systems with high efficiency to specific cell types by using passive and active targeting methods. After the development of a drug delivery system using PLGA nanoparticles, the drug is selectively delivered to the target site, and the effective blood concentration for extended periods of time is optimized according to the disease. In this review paper, we focus on ways to improve cell-specific treatment outcomes by examining the development of astrocyte selective nanoparticles based on PLGA nanomaterials for gene therapy.
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KEYWORD
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Astrocyte, gene therapy, nanoparticle, PLGA (Poly (D,L-lactic-co-glycolic acid))
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